Winatrec

 

WinAtrec Details

The original “bin” method: the AMPS solution in the Holter environment

WinAtrec is a software allowing the analysis of Continuous ECG recordings via the RR bin approach. WinAtrec (and in particular the RR bin approach) was used to assess drug-related changes on QRS and QT intervals.

The incorporated RR bin-approach, also referred as Selective Beat Averaging, is a module where individual QRS complexes are averaged according to the instantaneous heart-rate preceding them, a method that was shown to be particularly suited for the evaluation of drug-induced QT prolongation.
In addition of the RR-bin, WinAtrec offer the capability of performing time-based bins, where ECG beats in given time windows are averaged together to provide families of templates stratified over time.

Selective beat averaging is used to obtain averages of P-QRS-T complexes that are preceded by the same stable heart rate. This philosophy aims to respect the restitution curve of ventricular repolarization which demonstrates that full adaptation of QT interval to changes in heart rate is only achieved after a time period that can be longer than a minute. Thus, despite an identical RR interval, beats occurring "in the middle of heart rate changes" may have a different repolarization shape than those occurring at stable heart rate. Most of all, they will have a different QT duration.
RR-bin algorithm algorithm determines a family of templates stratified over the range of available RR intervals, where the stratification resolution (in msec) is user selectable and can be as small as 5 msec.

Due to the large file–size of Holter recordings, WinAtrec demo version is not available for automatic download from our website.

Here a list of papers outlaying the concepts of RR-bin method and its application, availbale on on the Publications page of our website:

A fundamental relationship between intraventricular conduction and heart rate, published in 2016.
Methodologies to characterize the QT/corrected QT interval in the presence of drug-induced heart rate changes or other autonomic effects, published in 2012.
Type 1 electrocardiographic burden is increased in symptomatic patients with Brugada syndrome, published in 2010.
Contrasting Time and Rate based approaches for the assessment of drug-induced QT changes, published in 2007.
Control of Rapid Heart Rate Changes for Electrocardiographic Analysis: Implications for Thorough QT Studies, published in 2006.
Quantitative assessment of ST segment elevation in Brugada patients, published in 2006.
Holter Monitoring for QT: Types of Analyses and Endpoints The RR Bin Method in Depth

WinAtrec Learn More

Here you can view an high level Overview of WinAtrec software, highlighting the main functionalities and features.
Given the complexity of WinAtrec we offer a one-hour free-of-charge webex demo to to show the interface and illustrate all the key features of this product. If you are interested please contact: support@amps-llc.com to schedule the webex.

execute